Imaging brain functional and metabolic changes in restless legs syndrome.
نویسندگان
چکیده
Even though the pathophysiology of restless legs syndrome is not completely understood, several imaging studies have contributed to our understanding of the disease. Functional and metabolic impairment seems to be the pathophysiological core, tied to a single brain network or multiple connected brain networks, via neurotransmitter modifications. Positron emission tomography and single photon emission computed tomography studies support a dysfunction of dopaminergic pathways, involving not only the nigrostriatal pathway but also the mesolimbic pathway. Furthermore, a possible role of serotonergic neurotransmission has been suggested. Functional magnetic resonance imaging studies have demonstrated in restless legs syndrome patients a pathologic activation of cerebral areas belonging to both the sensorimotor and the limbic networks. Proton magnetic resonance spectroscopy has confirmed abnormality of the limbic system and suggested the presence of a glutamatergic disorder. Finally magnetic resonance studies using iron-sensitive sequences have demonstrated reduced iron content in several regions of the brain of restless legs syndrome patients. In this review we attempt to integrate all current imaging study results into a convergent pathophysiological interpretation.
منابع مشابه
Multimodality Study for Restless Legs Syndrome: Morphological Changes in White and Gray matter
Introduction: Restless leg syndrome (RLS) is a sensory-motor disorder causing chronic sleep disturbances. Currently, neuroradiological investigations such as functional MRI, voxel-based relaxometry (VBR) as well as nuclear medicine have revealed a widespread pattern of pathological changes involving cerebra, cerebella and brain stem [1-3]. Thus, underlying mechanism of RLS is not well-understoo...
متن کاملPrevalence of Restless Legs Syndrome in Iranian Patients under Hemodialysis: A Systematic Review and Meta-Analysis Study
Introduction: Recent studies have contradictory reports of the overall prevalence of restless legs syndrome in hemodialysis patients. Therefore, the aim of this study was to help eliminate ambiguity about the prevalence of restless legs syndrome in Iranian hemodialysis patients by systematic review and meta-analysis study. Methods: This study was performed based on PRISMA checklist. Documents ...
متن کاملرابطه کمبود آهن و سندرم پاهای بیقرار در بیماران تحت همودیالیز
Introduction: Restless legs syndrome is a neurological disorder hemodialysis patients seem to suffer more from this syndrome. Although the pathophysiology of restless legs syndrome is still unknown, assessment of factors associated with this syndrome can help to develop medical knowledge in this field. The present study assessed the relationship between restless legs syndrome, serum iron, and s...
متن کاملMethods of Controlling Restless Legs Syndrome in Diabetic Patients: A Scoping Review Study
Introduction: ‘Restless Legs Syndrome’ is a sensory-motor disorder manifested by a tendency to move legs, usually accompanied by discomfort in the legs. Studies have shown that diabetics are more at risk for Restless Legs Syndrome than the general population. Therefore, a review study was designed to determine the methods of controlling restless legs syndrome in patients with diabetes. Methods:...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Current neurology and neuroscience reports
دوره 13 9 شماره
صفحات -
تاریخ انتشار 2013